专利详细信息

基于支持向量机和离子迁移谱的中草药产地鉴别方法

文献类型：专利

专利类型：发明专利

是否失效：否

是否授权：否

申请号：CN201310095950.2

申请日：20130325

发明人：姜久英刘军刘芸王国祥王海燕

申请人：江苏易谱恒科技有限公司

申请人地址：210000 江苏省南京市白下路273号

公开日：20130814

公开号：CN103245713A

代理人：杨海军

代理机构：32200 南京经纬专利商标代理有限公司

语　　种：中文

摘　　要：本发明公开一种基于支持向量机和离子迁移谱的中草药产地鉴别方法，该方法以离子迁移谱分析技术为检测手段，以支持向量机分析技术为识别方法，将模式识别技术与谱图分析技术相结合，提供一种适用于中草药产地鉴别的方法。本发明提供的中草药产地鉴别方法，具有快速、准确的优点，可以解决我国中药材安全不可靠、质量不可控的研究现状，对保证药材质量和临床用药安全具有重要意义。

主权项：1.基于支持向量机和离子迁移谱的中草药产地鉴别方法，其特征在于包括中草药前处理，中草药离子迁移谱图信息采集、谱图数据分析和ＳＶＭ分类器的构建；（1）中草药前处理包括以下步骤：取中草药粉碎、干燥后加入乙醇，采用超声提取法或浸渍提取法，合并提取液，浓缩，溶液过0.45μm滤膜后得到供试品；（2）中草药离子迁移谱图信息采集包括以下步骤：利用微量进样器量取5μl步骤（1）得到的供试品，注入约1ml的玻璃样瓶中，将玻璃瓶置于进样处，采集样品的挥发性气体，具体参数为：迁移管温度为100～200℃，载气速度为0.4～1.0ml/min，漂气速度为0.6～1.0ml/min；（3）谱图数据分析和ＳＶＭ分类器的构建：采用PCA的方法对中草药离子迁移谱图的原始数据矩阵进行数据降维，记离子迁移谱样本训练集为 $<math> <mrow> <mrow> <mo>(</mo> <msub> <mover> <mi>α</mi> <mo>&RightArrow;</mo> </mover> <mn>1</mn> </msub> <mo>,</mo> <msub> <mi>l</mi> <mn>1</mn> </msub> <mo>)</mo> </mrow> <mo>,</mo> <mrow> <mo>(</mo> <msub> <mover> <mi>α</mi> <mo>&RightArrow;</mo> </mover> <mn>2</mn> </msub> <mo>,</mo> <msub> <mi>l</mi> <mn>2</mn> </msub> <mo>)</mo> </mrow> <mo>,</mo> <mo>.</mo> <mo>.</mo> <mo>.</mo> <mo>,</mo> <mrow> <mo>(</mo> <msub> <mover> <mi>α</mi> <mo>&RightArrow;</mo> </mover> <mi>n</mi> </msub> <mo>,</mo> <msub> <mi>l</mi> <mi>n</mi> </msub> <mo>)</mo> </mrow> <mo>,</mo> </mrow></math>$ $<math> <mrow> <mo>&PartialD;</mo> <mo>=</mo> <mo>[</mo> <msub> <mover> </p><p class='subject'><strong>关键词：</strong><b class='type_ico_id'></b>中草药 <b class='type_ico_id'></b>离子迁移谱分析技术鉴别方法产地 <b class='type_ico_id'></b>向量机 <b class='type_ico_id'></b>临床用药安全 <b class='type_ico_id'></b>模式识别技术技术相结合研究现状 <b class='type_ico_id'></b>药材质量重要意义图分析中药材检测 </p><p class='class'><strong>IPC专利分类号：</strong>G01N27/62(20060101)</p>
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