文献类型：会议

作　　者：刘建军

作者单位：新加坡基因组研究所

会议文献：中华医学会第十二次全国皮肤性病学术会议论文集

会议名称：中华医学会第十二次全国皮肤性病学术会议

会议日期：20060000

会议地点：中国安徽合肥

主办单位：中华医学会

出版日期：20060000

学会名称：中华医学会

语　　种：中文

摘　　要：Involvement of genetic risk factors has well been established for human common disorders. Many high-penetrance genetic risk factors for common disorders have been identified by family-based linkage analysis, such as BRCA1 and BRCA2 for breast cancer, but these factors generally account for only a small proportion of genetic risk. The remaining genetic risk is likely to be explained by a polygenic model where disease susceptibility is conferred by a large number of low-penetrance alleles. The risk conferred by each of these alleles may be small but these alleles may combine additively or multiplicatively to affect disease susceptibility substantially. Therefore, further

关 键 词：New Frontier for the Genetic Study of Human Common Disorders:Whole-genome Association Analysis  

分 类 号：R596]