文献类型：期刊文章

作　　者：葛志军[1] 戴体俊[1] 曾因明[1]

机构地区：[1]江苏省麻醉医学研究所江苏省麻醉学重点实验室

出　　处：《国际麻醉学与复苏杂志》

年　　份：2006

卷　　号：27

期　　号：2

起止页码：103-105

语　　种：中文

收录情况：CAS、JST、ZGKJHX、普通刊

摘　　要：Ropivacaine is pure(S-enantiomer) amino-amide local anaesthetic.Especially its better cardiotoxic profile than identical concentrations of bupivacaine has been well documented.The clear advantages of the long duration of action,and extensive margin of safety,and powerful analgesic effect and sensory-motor differential block(at lower concentrations) seen with ropivacaine relative to bupivacaine will be advantageous in certain applications.The physico-chemical properties of ropivacaine suggest that its rate of onset(related to pKa) should be similar to that of bupivacaine,and that its absolute potency(lipid solubility) and duration of effect(protein binding) should be sightly less.Ropivacaine has been introduced into clinical practice recently including infiltration anesthesia,nerve block,epidural block,spinal anesthesia, painless birth,and post-surgical analgesia.Based on available clinical data, ropivacaine appears to be as effective as bupivacaine when equal analgesic doses are

关 键 词：罗哌卡因 临床麻醉 心脏毒性作用 局部麻醉药 其临床应用  布比卡因 使用趋势  理化特性  致命性

分 类 号：R614]