文献类型：期刊文章

作　　者：张亚洲[1,2] 徐风[3] 易涛[1] 张建业[1] 汤依娜[1] 许军[1] 彭宛龄[1] 陈虎彪[1]

机构地区：[1]香港浸会大学中医药学院,香港九龙塘999077 [2]贵州理工学院制药工程学院,贵州贵阳550003 [3]北京大学医学部天然及仿生药物国家重点实验室,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》

基　　金：Hong Kong Baptist University Faculty Research Foundation(Grant No.FRG2/12-13/058);the Key Program of Guangxi Natural Science Foundation of China(Grant No.2013-GXNSFBA019187)

年　　份：2014

卷　　号：23

期　　号：9

起止页码：631-641

语　　种：中文

收录情况：CAB、CAS、CSCD、CSCD2013_2014、DOAJ、EMBASE、IC、JST、SCOPUS、ZGKJHX、普通刊

摘　　要：The fragmentation behavior of isoflavones was studied using electrospray ionization-ion trap-time of flight mass spectrometry （ESI-IT-TOF-MSn）. It was found that the isoflavone glycoside bond was easily broken. The fragmentation occurred mostly on the C-ring, and the fragment ions of A^1,3＋ produced by the RDA cracking will predict the hydroxylation replacement on A-ring or B-ring. In addition, four carbonyl groups on the C-ring were fragmented through neutral loss of 28 （-CO）. A and B-rings primarily lose substituents which including a neutral losses of 32 （-CH3OH）, 16 （-CH4）, or 16 （-O）, and 18 （-H2O）. A-ring in the presence of adjacent hydroxylation, also easily made to be a neutral losses of 28 （-CO） or 18 （-H20）. It is likewise common to see methoxy replaced with a neutral losses of 16 （-CH4） or 32 （-CHaOH） in B-ring, also the hydroxylation on benzene ring can occasionally results with the neutral loss of 28 （-CO）.

关 键 词：ISOFLAVONE Fragmentation behavior  ESI-IT-TOF-MSn  

分 类 号：R284.1[中药学类] O657.63[中医学类]