文献类型：期刊文章

作　　者：WANG Xiaotong[1] HUANG Hanjin[1] DONG Qiqian[1] LIN Yan[1] WANC Zongmin[2] LI Fangqu[3] Yukifumi Nawa[4] Kentars Yoshimura[5]

王小同;黄汉津;董其谦;林燕;王宗敏;李方去;Yukifumi Nawa;Kentars Yoshimura(温州医学院附属第二医院,浙江温州,325000;日本宫崎医科大学寄生虫学研究室,日本宫崎市,889;日本秋田大学医学部寄生虫学研究室,日本,010)

机构地区：[1]Department of Neurology,Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China [2]Department of Pathology.Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China [3]Laboratory of the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China [4]Department of Parasitology,MiyazakaMedical College,Japan [5]Department of Parasitology,School of Medicine,Akita University,Japan

出　　处：《Chinese Medical Journal》

年　　份：2002

期　　号：9

起止页码：1312-1315

语　　种：中文

收录情况：CAB、CAS、CSCD、CSCD2011_2012、DOAJ、EAPJ2020、EBSCO、EMBASE、IC、JST、PROQUEST、PUBMED、SCIE、SCOPUS、WOS、ZGKJHX、普通刊

摘　　要：Objective To improve the clinician's awareness of angiostrongyliasis.Methods The clinical and laboratory data as well as the epidemiological information concerning 18 patients with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis were analyzed.Results All patients had a history of eating raw fresh water snail(Ampularium canaliculatus)before the onset of the disease.Incubation period ranged from 1 to 25 days.The major symptoms of the patients had severe headache and pain in the trunk and limbs.Increased eosinophlic count in peripheral blood and cerebrospinal fluid was noted.Tested by enzyme-linked immunoadsorbent assay(ELISA),sera were specifically lgG-antibody positive against Angiostrougylus cantonensis antigen,but were negative against other parasitic antigens such as Paragonimus westermani.Cysticerus,Cellulosae hominis,Echinococcus granulosus and Trichinella spiralis.Abnormal spotty signals were found in 2 cases with brain magnetic resonance imaging.Electroencephalogram(EEG)showed slow alpha rhythm.All the patients were effectively treated with combined administration of albendazole and dexamethazone.Conclusions Angiostrongyliasis is one of the common causes leading to eosinophilic meningoencephalitis.To our knowledge,Wenzhou is the first small outbreak site of angiostrongyliasis discovered in Chinese mainland.

关 键 词：STRONGYLIDA INFECTIONS MENINGOENCEPHALITIS

分 类 号：R532.1]