文献类型：期刊文章

作　　者：赵同标[1] 赵新全[1] 常智杰[2] 朱姗姗[2] 赵伟[1] 孙平[1] 徐世晓[1]

机构地区：[1]中国科学院西北高原生物研究所,西宁810001 [2]清华大学生物科学与技术系基因组研究所,北京100084

出　　处：《兽类学报》

基　　金：国家基础研究规划项目 (G19980 40 813 ) ;中国科学知识创新工程项目 (KZCX1 0 1 0 1) ;中国科学院海北高寒草甸生态系统开放试验站基金

年　　份：2003

卷　　号：23

期　　号：3

起止页码：273-276

语　　种：中文

收录情况：AJ、BDHX、BDHX2000、BIOSISPREVIEWS、CAS、CSCD、CSCD2011_2012、GEOBASE、IC、JST、PUBMED、SCOPUS、WOS、ZGKJHX、ZR、核心刊

摘　　要：Hypoxia induced factor 1 plays a key role during the cell hypoxia tran sduction Hypoxia induced factor 1α (HIF 1α) is a functional subunit of hyp oxi a induced factor 1 Plateau pika ( Ochotona curzoniae ),which is a Qinghai Tibet plateau native animal lived above 3 000 m,has high ratio of oxygen util ization to adapt to plateau hypoxia environments One fragment of the coding region of cDN A sequence of plateau pika HIF 1α was obtained by RT PCR technique using a deg en eracy PCR primer based on previously reported cDNA sequence in human, cattle, ho use mouse and Norway rat HIF 1α gene It was directly inserted into the vecto r pMD18 T DNA sequencing proved that it was highly homology with human (91%), c at tle (91%), house mouse (89%) and Norway rat (89%) HIF 1α gene The study prov id es basic important information for the HIF 1α cDNA whole sequence cloning of p lateau pika and its functional

关 键 词：高原鼠兔 低氧诱导因子—1α  红细胞生成素 增强子

分 类 号：Q959.836] Q953